µFLUX™

Combining the data from a dissolution experiment with trans-membrane permeation, the µFLUX™ system is the perfect tool for making early pharmacokinetic decisions.
 

Whether assessing the effect different formulation vehicles have on FLUX, or assessing pre-clinical performance based on pH or food, Pion’s µFLUX™ is a convenient and powerful in vitro tool. This novel solution will allow you to easily conduct small volume, in situ concentration monitoring, and at the same time evaluate the absorption potential of your compound as you separate the receiver and donor chambers with a membrane. The µFLUX™ also allows you to control for temperature and stirring.

 

 

 

 

 

Case Studies 

 

 

     
Case Study 1: Formulation FLUX Enhancement Case Study 2: Formulation FLUX Inhibition Case Study 3: FLUX Effect of Supersaturation

 

 

 

View this poster from AAPS describing the µFLUX set up

 

 

 Case Study 1-Formulation FLUX Enhancement


 Case Study 2-Formulation FLUX Inhibition


 Case Study 3-FLUX Effect of Supersaturation

 

Additional Resources