Overview

Services

Compound Profiling

Pion's Contract Research Services expertise is an ideal solution to help you profile the pharmaceutical properties of your candidate compounds. Pion delivers rapid, accurate, and reproducible results for Ionization, , Solubility, Dissolution, Permeability, Absorption and Lipophilicity. That allows you to improve your compounds' in vivo performance in lead generation, optimization, and selection. Better leads, in turn, translate directly to better utilization of your scarce resources.

 

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Formulation Development

Combine all of Pion's experience, technology and expertise into your drug development plan.  Allow Pion to be your partner as you look to optimize your drug substance for its physical chemical properties.  Pion's team of technical professionals, and state of the art laboratory are the perfect add-on to assist any size company in the optimization and determination of ionization, solubility, dissolution, permeability, absorption and lipophilicty.

 

 

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Capabilities

 Ionization

 

 Solubility

 

 Dissolution

 

Permeability Absorption Lipophilicity

 

 

 

Ionization

Pion’s expertise in the area of pKa, log P/D and potentiometric solubility determination is unsurpassed. Services are also available with in situ UV detection for low soluble compounds.  The Pion PULSE instrument is the perfect solution for all of your ionization and lipophilicity needs. With hardware and software designed and developed within Pion’s own analytical laboratory, Pion is sure to provide your lab with robust data and comprehensive reporting.

 

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Solubility

Utilizing Pion's small volume shake flask solubility method, Pion can deliver to you, the customer, accurate and robust solubility data utilizing a minimal amount of costly API.  Performed within a well-plate format, the Pion µSOL method allows for screening across multiple pHs, screening across multiple buffers and bio relevant systems, and even screening formulation vehicles for enhancement of permeability through an increase in solubility.

 

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Dissolution

The precise monitoring of a drug products dissolution rate is an area where Pion technology and experience can benefit your formulation method development.  Utilizing a variety of industry standard USP 1 and 2 systems, Pion's Analytical Lab is equipped to provide you the maximum amount of information for all of your dissolution profiling needs.

 

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Permeability

Pion PAMPA, currently available in GIT, BBB and Skin models, is the most scientifically robust commercial model available today.  Utilize Pion PAMPA (Parallel Artificial Membrane Permeability Assay) for the determination of a compounds passive permeability. With close to two decades of experience, publications and hands-on experience, choose Pion for all of your passive permeability screening needs.

 

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Absorption

Pion has pioneered reliable methods for predicting the absorption potential of finished dosage products prior to clinical trials. New testing technology allows Pion to combine traditional dissolution testing with repeatable methods for assessing the absorption potential of APIs, API/ingredient combinations, or finished dosage products. As a result, Pion can more reliably and realistically test and model IVIVC (in vitro-in vivo correlation). Pion’s approach allows potential problems with the permeability and absorption potential of a promising compound to be identfied far earlier in the development process. In addition, Pion’s can accurately predict the absorption potential and bioequivalence of various finished dosage products earlier in development. This capability facilitates better decision-making and resource allocation by pharmaceutical developers.

 

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Lipophilicity

Pion measures lipophilicity with octanol/water and other partitioning media such as cyclohexane, heptane, and liposomes.

 

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