Log P is a measure of lipophilicity, or the ratio of compound that partitions between octanol and water. As the value increases, so does the lipophilicity of the compound. The determination is based on potentiometric titration, with results comparable to the shakeflask technique. Results are reported using the lipophilicity profile, a plot of log D versus pH. We routinely measure log P between -2 and 5.
Potentiometric titration is especially useful for zwitterions and problems associated with ion-pair formation, and micro-emulsion in the shake-flask method. pION has the capability to perform experiments with other partitioning media such as cyclohexane, heptane, and liposomes.
To submit your compounds for analysis:
