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pION INC.
Home Click here to learn about pION's history, its founders, and the latest company news Products Find out about pION's cost-effective analytical services to measure your compounds Find out where pION scientist will be speaking, where pION is exhibiting, as well as training courses and seminars Find citations and order books with the latest scientific developments from pION Contact us
PAMPA Evolution
PAMPA Explorer
µSOL Evolution
µSOL Explorer
pSOL Gemini
Gut-Box
Evolution Library Manager
ADME Boxes
Rainbow Dynamic Dissolution Monitor
µDISS Profiler
 
 

pION has a range of products for physicochemical compound characterization:
 
 Permeability

  PAMPA Evolution™

pION's high-throughput instrument for determining permeability in a 96-well microtiter plate format by PAMPA (parallel artificial membrane permeability) method. Available on either Tecan or Beckman robotic platforms.
 

  PAMPA Explorer™

pION's entry level system for determining permeability by PAMPA method.
 

  Gut-Box™

new accessory for pION PAMPA systems (stirring apparatus that mimics GUT conditions).
 

 Solubility

  µSOL Evolution™

pION's high-throughput instrument for determining solubility in a 96-well microtiter plate format by dilution method. Available on either Tecan or Beckman robotic platforms.
 

  µSOL Explorer™

pION's entry level system for determining solubility.
 

  µDISS Profiler™
  		Small volume solubility apparatus for detailed examination of polymorph and salt screening; excipient characterization; and FeSSIF/FaSSIF studies.
  Gemini Profiler™

pION's automated instrument for determining intrinsic solubility, pH-solubility profiles, ionization constants, pKa, and log P/log D, pH-lipophilicity profiles by dissolution titration method.
 

 Dissolution

  Rainbow Dissolution Monitor
 

Multi-channel UV fiber optic detection system

  µDISS Profiler™
  		Small volume dissolution apparatus.
 
  Mini-IDR™
  		Compression accessory for µDISS Profiler from Heath Scientific
 
 Software

  pCEL-X™

Request a Demo CD

Software tool for simulation and refinement of Caco-2 and PAMPA pH-dependent permeability data developed by pION INC.

 

  Evolution Library Manager
  (ELM™)
 

µSOL and PAMPA Evolution data management software developed by pION INC.
 

  ADME Boxes

in silico property prediction and calculation.
 

   
Please click here for the list of local manufacturer's reps and worldwide distributors.
 
 Permeability compound's ability to permeate through a phospholipid model membrane
 
 Solubility compound's ability to dissolve in water or water-miscible organic solvents, as a function of pH
 
 pKa ionization constant: the pH at which the concentrations of the neutral species and the charged species are equal
 
 log P oil-water partition coefficient, independent on pH
 
 logD apparent partition coefficient, dependent on pH
 

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