Papers

Permeability Series
Solubility Series
pKa Series



A list of PAMPA References (PDF)
	pION's Permeability Map featured on the cover of Pharmaceutical Research Journal Click the image for larger picture
Escher BI, Berger C, Bramaz N, Kwon J-H, Richter M, Tsinman O, Avdeef A. Membrane-water partitioning, membrane permeability and non-target modes of action in aquatic organisms of the parasiticides ivermectin, ablendazole and morantel. Envir. Tox. Chem. 2008, 27, 000-000. (Part 25 PAMPA series) Avdeef A, Bendels S, Di L, Faller B, Kansy M, Sugano K, Yamauchi Y. PAMPA - a useful tool in drug discovery. J. Pharm. Sci. 2007, 96, 2893-2909. (Part 24 in PAMPA Series) Avdeef A, Kansy M, Bendels S, Tsinman K. Absorption-excipient-pH classification gradient maps: sparingly-soluble drugs and the pH partition hypothesis. Eur. J. Pharm. Sci. 2008, 33, 29-41. (Part 23 PAMPA Series) Avdeef, A.; Bendels, S.; Tsinman, O.; Tsinman, K.; Kansy, M. Solubility-Excipient Classification Gradient Maps. Pharm. Res., 2007, 24, 530-545. (Part 22 in PAMPA series). Available on-line through SpringerLink. Bendels, S.; Tsinman, O.; Wagner, B.; Lipp, D.; Parilla, I.; Kansy, M.; Avdeef, A. PAMPA-Excipient Classification Gradient Map. Pharm. Res., 2006, 23, 2525-2535. (Part 21 in PAMPA series). Available on-line through SpringerLink. Fischer, H.; Kansy, M., Avdeef, A.; Senner, F. Permeation of permanently charged molecules through artificial membranes – influence of physico-chemical properties. Eur. J. Pharm. Sci. 2007, 31, 32-42. (Part 20 in PAMPA series). Available on-line through ScienceDirect. Avdeef, A. The Rise of PAMPA. Expert Opinion on Drug Metab. Tox., 2005, 1, 325-342. (Part 17 in PAMPA series) Kansy, M.; Avdeef, A.; Fischer, H. Advances in Screening for Membrane Permeability: High-Resolution PAMPA for Medicinal Chemists. Drug Discovery Today: Technologies, 2005, 1, 349-355. (Part 16 in PAMPA series) Ruell, J.A.; Avdeef, A. Absorption using the PAMPA Approach. In: Yan, Z.; Caldwell, G.W. (Eds.), Optimization in Drug Discovery: In Vitro Methods. The Humana Press: Totowa, NJ, 2004, pp. 37-64. (Part 15 in PAMPA series) Avdeef, A. HT Solubility and Permeability: MAD-PAMPA Analysis. In: Krämer, S.D.; Folkers, G.; Testa, B. (Eds.), Physicochemical and Biological Profiling in Drug Research. Wiley-VCH: Weinheim, 2004, pp. 221-241. (Part 14 in PAMPA series) Avdeef, A.; Tsinman, O. PAMPA – a Drug Absorption in vitro Model. 13. Chemical Selectivity due to Membrane Hydrogen Bonding: in combo Comparisons of HDM-, DOPC-, and DS-PAMPA. Eur. J. Pharm. Sci., 2006, 28(1-2), 43-50. (Part 13 in PAMPA series). Available on-line through ScienceDirect. Ruell, J.A.; Tsinman, O.; Avdeef, A. Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules. Chem. Pharm. Bull., 2004, 52, 561-565. (Part 12 in PAMPA series) Rated #12 on the List of ScienceDirect TOP25 Hottest Articles - Jul-Sep 2004 Avdeef, A.; Nielsen, P.E.; Tsinman, O. PAMPA - a Drug Absorption in vitro Model. 11. Matching the in vivo Unstirred Water Layer Thickness by Individual-Well Stirring in Microtitre Plates. Eur. J. Pharm. Sci., 2004, 22, 365-374. (Part 11 in PAMPA series). Available on-line through ScienceDirect. Caron, G.; Ermondi, G.; Damiano, A.; Novaroli, L.; Tsinman, O.; Ruell, J.A.; Avdeef, A. Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine. Bioorg. Med. Chem., 2004, 23, 6107-6118. (Part 10 in PAMPA series) Most Sited Paper Award 2005 from European Journal of Pharmaceutical Sciences. Rated #15 on the List of ScienceDirect TOP25 Hottest Articles - Apr-Jun 2005 Avdeef, A.; Artursson, P.; Neuhoff, S.; Lazarova, L.; Gråsjö, J.; Tavelin, S. Caco-2 Permeability of Weakly Basic Drugs Predicted with the Double-Sink PAMPA pK_a^flux Method. Eur. J. Pharm. Sci., 2005, 24, 333-349. (Part 9 in PAMPA series). Available on-line through ScienceDirect. Nielsen, P.; Avdeef, A. PAMPA - a Drug Absorption in vitro Model. 8. Apparent Filter Porosity and the Unstirred Water Layer. Eur. J. Pharm. Sci., 2004, 22, 33-41. (Part 8 in PAMPA series). Available on-line through ScienceDirect. Most Sited Paper Award 2004 from European Journal of Pharmaceutical Sciences. Bermejo, M.; Avdeef, A.; Ruiz, A.; Nalda, R.; Ruell, J.A.; Tsinman, O.; González, I.; Fernández, C.; Sánchez, G.; Garrigues, T.M.; Merino, V. PAMPA - a drug absorption in vitro model. 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur. J. Pharm. Sci., 2004, 21,429-441. (Part 7 in PAMPA series). Available on-line through ScienceDirect. Youdim, K.A.; Avdeef, A.; Abbott, N.J. In vitro trans-monolayer permeability calculations: often forgotten assumptions. Drug Disc. Today, 2003, 8, 997-1003. (Part 6 in PAMPA series) Ruell, J.A.; Tsinman, K.L.; Avdeef, A. PAMPA - a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pK_a^flux - optimized design (pOD-PAMPA). Eur. J. Pharm. Sci., 2003, 20, 393-402 (Part 5 in PAMPA series). Available on-line through ScienceDirect. Liu, H.; Sabus, C.; Carter, G.T; Du, C.; Avdeef, A.; Tischler, M. In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection. Pharm. Res., 2003, 20, 1820-1826. (Part 4 in PAMPA series). Available on-line through SpringerLink. Avdeef, A. High-throughput Measurement of Membrane Permeability. In: H. van de Waterbeemd, H. Lennernäs, P. Artursson (Eds.). Drug Bioavailability/Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley-VCH: Weinheim, 2003, pp. 46-71. (Part 3 in PAMPA series) Avdeef, A.; Strafford, M.; Block, E.; Balogh, M.P.; Chambliss, W.; Khan, I. Drug Absorption In Vitro Model: Filter-Immobilized Artificial Membranes. 2. Studies of the Permeability Properties of Lactones in Piper methysticum Forst. Eur. J. Pharm. Sci., 2001, 14, 271-280. (Part 2 in PAMPA series). Available on-line through ScienceDirect. Avdeef, A. High-throughput measurements of solubility profiles. In: Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R. (Eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH: Weinheim, 2001, pp. 305-326. (Part 1 in PAMPA series) Avdeef, A. Absorption and Drug Development. Wiley-Interscience: New York. 2003. Didžiapetris, R.; Japertas, P.; Avdeef, A.; Petrauskas, A. Classification analysis of P-glycoprotein substrate specificity. J. Drug Target, 2003, 11, 391-406. Ruell, J. Membrane-based Drug Assays. Modern Drug Disc., 2003, January issue, 28-30. Žmuidinavicius, D.; Didžiapetris, R.; Japertas, P.; Avdeef, A.; Petrauskas, A. Classification structure-activity relations (C-SAR) in prediction of human intestinal absorption. J. Pharm. Sci., 2003, 92, 621-633. Avdeef, A.; Testa, B. Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques. Cell. Molec. Life Sci., 2003, 59, 1681-1689. Available on-line through SpringerLink. Avdeef, A. Physicochemical Profiling (Permeability, Solubility, Charge State). Curr. Topics Med. Chem., 2001, 1, 277-351.




Berger CM, Tsinman O, Voloboy D, Lipp D, Stones S, Avdeef A. Miniaturized intrinsic dissolution rate (Mini-IDR™) measurement of griseofulvin and carbamazepine. Dissolut .Tech. 2007, 14, 39-41. (Part 9 in the pSOL Series) Avdeef A. Solubility of sparingly-soluble drugs. Dressman J, Reppas C. (Eds., special issue: The Importance of Drug Solubility). Adv. Drug Deliv. Rev. 2007, 59, 568-590. (Part 8 in pSOL series) Avdeef A, Bendels S, Tsinman O, Kansy M. Solubility-excipient classification gradient maps. Pharm. Res., 2007, 24, 530-545. Avdeef A. Drug ionization and physicochemical profiling. In: Mannhold, R. (Ed.), Drug Properties: Measurement and Computation, Wiley-VCH, 2007, pp. 55-83. Avdeef, A.; Voloboy, D.; Foreman, A. Dissolution – Solubility of Multiprotic Drugs: pH, Buffer, Salt, Dual-Solid, and Aggregation Effects. In: Testa, B.; van de Waterbeemd, H. (Eds.). Comprehensive Medicinal Chemistry II, Vol. 5 ADME-TOX Approaches. Elsevier: Oxford, UK, 2006, pp. 399-423. (Part 7 in pSOL series) McFarland, J.W.; Du, C.M.; Avdeef, A. Factors influencing the water solubility of crystalline drugs. In: van de Waterbeemd, H.; Lennernäs, H.; Artursson, P.(Eds.). Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley - VCH: Weinheim, 2003, pp. 232-242. (Part 6 in pSOL series) McFarland, J.W.; Avdeef, A.; Berger, C.M.; Raevsky, O.A. Estimating the water solubilities of crystalline compounds from their chemical structure alone. J. Chem. Inf. Comput. Sci., 2001, 41, 1355-1359. (Part 5 in pSOL series). Available on-line through ACS. Bergström, C.A.S.; Strafford, M.; Lazarova, L.; Avdeef, A.; Luthman, K.; Artursson, P. Absorption classification of oral drugs based on molecular surface properties. J. Med. Chem., 2003, 46, 558-570. (Part 4 in pSOL series) Download PDF of this article (free access through ACS) Avdeef, A.; Berger, C.M. pH-Metric Solubility. 3. Dissolution Titration Template Method for Solubility Determination. Eur. J. Pharm. Sci., 2001, 14, 271-280. (Part 3 in pSOL series). Available on-line through ScienceDirect. Avdeef, A.; Berger, C.M.; Brownell, C. pH-Metric Solubility. 2. Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods. Pharm. Res., 2000, 17, 85-89. (Part 2 in pSOL series). Available on-line through SpringerLink. Avdeef, A., . pH-Metric Solubility. 1. Solubility-pH Profiles from Bjerrum Plots. Gibbs Buffer and pKa in the Solid State. Pharm. Pharmacol. Commun., 1998, 4, 165-178. (Part 1 in pSOL series) Avdeef, A. Absorption and Drug Development. Wiley-Interscience: New York. 2003. Avdeef, A.; Testa, B. Physicochemical profiling in drug research: a brief state-of-the-art of experimental techniques. Cell. Molec. Life Sci., 2003, 59, 1681-1689. Ruell, J.; Avdeef, A. A measured solution. Modern Drug Disc., 2003, June issue, 47-49. Avdeef, A. Physicochemical Profiling (Permeability, Solubility, Charge State). Curr. Topics Med. Chem., 2001, 1, 277-351.

Avdeef, A. Drug ionization and physicochemical profiling. In: Mannhold, R. (Ed.), Drug Properties: Measurement and Computation, Wiley-VCH, 2007, pp. 55-83. (Part 1 in pKa series)