Eight Position Mini-Bath™ Introduced for µDISS Profiler™

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A new Mini-Bath™ upgrade from the previous six position bath features fully independent, computer controlled stirring for ultimate flexibility with API-sparing tests using biorelevant media.

pION INC announces the launch of its 8-position Mini-Bath as an integral part of the best-selling fiber optic detection system, the 8-channel µDISS Profiler™. This design is a continuation of improvements brought about by suggestions from our users of the 6-channel Mini-Bath™. The two additional channels offer additional possibilities in experimental design, such as inclusion of a permanent standard or more pH points for dissolution pH profiling or more points for profiling stirring or media effects.

The Mini‑Bath™ allows dissolution experiments in solution volumes as low as 1 to 25 mL with simulated or human intestinal fluids when only small amounts of API are available. Powder and rotating disk intrinsic dissolution experiments can also be performed. These API-sparing intrinsic dissolution measurements correlate perfectly with data from traditional large volume data used in late development stage testing.

The computer controlled stirring of the Mini-Bath™ provides full independent control for all eight sample positions. Stirring can be initiated manually, automatically, or any combination of the two schemes. This allows complete flexibility in the design of experiments so that even dissolution tests of different APIs can be conducted within the same run. Also, a redesigned probe holder on the bath features a longer slot for easy and accurate probe alignment.

“Some of the best product ideas and improvements come from our dedicated customers who use our equipment”, said Alex Avdeef, CSO and co-founder of pION. “We consider their suggestions, refine and then implement them. We’re happy to provide this improved version of the Mini-Bath™ which demonstrates our commitment to our customers and our technologies to make even more reliable absorption related measurements possible. We take pride in our unique technical position as the industry respected experts in the ‘A’ of ADME.”

pION has been granted US and foreign patents on the dynamic in situ data acquisition and presentation along with a patent for hollow shaft measurement.