At pION, we specialize in the measurement of absorption related physicochemical parameters such as permeability, solubility, dissolution, and ionization. Our instruments allow Biopharmaceutical companies to conduct early phase screening of their drug compounds using API-sparing methods that will identify and focus scarce research resources on the most promising candidates.
| PAMPA Evolution™ |
pION's high-throughput instrument for determining permeability in a 96-well microtiter plate format using the Parallel Artificial Membrane Permeability Assay (PAMPA) method. Available on either the Tecan or Beckman robotic platforms. |
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| PAMPA Explorer™ |
pION's entry level instrument for determining permeability using the PAMPA method. |
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| Gut-Box™ |
An accessory for pION's PAMPA systems. A stirring apparatus for 96-well plates that mimics the human jejunum. |
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| µSOL Evolution™ |
pION's high-throughput instrument for determining solubility in a 96-well microtiter plate format using the dilution method. Available on either the Tecan or Beckman robotic platforms. |
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| µSOL Explorer™ |
pION's manual (non-robotic) entry level instrument for determining solubility in a 96-well microtiter plate format. |
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| µDISS Profiler™ |
Small volume solubility instrument for detailed examination of polymorph and salt screening, excipient characterization, and studies using media simulating fed (FeSSIF) and fasted (FaSSIF) states. |
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| Rainbow RDDM |
Multi-channel UV fiber optic detection system for dissolution QC |
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| µDISS Profiler™ |
API-sparing UV instrument with fiber optics for dissolution research |
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| Mini-IDR™ |
µDISS Profiler™ accessory from Heath Scientific |
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| Gemini Profiler™ |
pION's instrument for determining pKa, log P / log D, intrinsic solubility, and pH-solubility profiles. |
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| pCEL-X™ |
Software tool for simulation and refinement of Caco-2 and PAMPA pH-dependent permeability data developed by pION INC. |
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| Evolution Library Manager |
µSOL and PAMPA Evolution™ data management software developed by pION INC. |
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Please click here for the list of distributors and representatives.
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Definitions
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| Permeability: |
compound's ability to permeate through a phospholipid model membrane
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Solubility:
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compound's ability to dissolve in water or water-miscible organic solvents, as a function of pH
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pKa:
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ionization constant: the pH at which the concentrations of the neutral and charged species are equal
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lop P:
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oil-water partition coefficient, independent of pH
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log D:
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apparent partition coefficient, dependent on pH
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