Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.

Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules can be found in the book.

The gold standard for intrinsic solubility results is for the first time, available to you for use in your lab. This quick reference guide provides over 250 pages of intrinsic solubility results for common compounds. The Compendium displays the solubility profile for each of 22 compounds at varying pH's.

*NEW*
Avdeef, A. Drug Ionization and Physicochemical Profiling. In: Mannhold, R. (Ed.), Molecular Drug Properties: Measurement and Prediction, Wiley-VCH, 2007, pp. 55-83, ISBN: 978-3-527-31755-4.
 

*NEW*
Avdeef, A.; Voloboy, D.; Foreman, A. Dissolution and Solubility. In: B. Testa, H. van de Waterbeemd (eds.), Comprehensive Medicinal Chemistry II, Volume 5: ADME-TOX Approaches, Elsevier: Oxford, UK, 2007, pp. 399-423, ISBN 0-08-044513-6.
 

Comprehensive Medicinal Chemistry II is designed as an essential reference work for medicinal chemists and also for scientists and workers in the broader area of pharmaceutical and biotechnology sciences.

Avdeef, A. HT Solubility and Permeability: MAD-PAMPA Analysis. In: B. Testa, S.D. Krämer, H. Wunderli-Allenspach, G. Folkers (eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH: Weinheim, 2006, pp. 221-241, ISBN 978-3-90639-035-2.
 

Avdeef, A.; Ruell, J.A. Absorption using the PAMPA Approach. In: Z. Yan, G.W. Caldwell (eds.), Optimization in Drug Discovery: In Vitro Methods, The Humana Press: Totowa, NJ, 2004, pp. 37-64, ISBN 1-58829-332-7.
 

A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, absorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.

Avdeef, A. High-throughput Measurement of Membrane Permeability. In: H. van de Waterbeemd, H. Lennernäs, P. Artursson (eds.), Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability, Wiley-VCH: Weinheim, 2003, pp. 46-71, ISBN 3-527-30438-X.
 

Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability.

Avdeef, A. High-throughpur Measurements of Solubility Profiles. In: B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy (eds.), Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies, Verlag Helvetica Chimica Acta: Zürich and Wiley-VCH: Weinhem, 2001, pp. 305-326, ISBN 3-906390-22-5.
 

In this work of unique breadth and depth, internationally recognized authorities from academia and industry present the most modern biological, physicochemical, and computational approaches for optimization of pharmacokinetic properties.

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