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pION INC.
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Click on the links below to download instrument brochures, technical specification sheets, services required for the installation and posters in pdf format. Need Adobe Acrobat® Reader™? Click here!

 
 
*NEW*
µDISS Profiler µDISS Profiler™ - Small Volume Dissolution and Solubility Apparatus
Brochure TechNote 1 Spec Sheet
TechNote 2 Installation Requirements
TechNote 3
TechNote 4
*NEW*
Mini-IDR Mini-IDR™ - Compression Accessory for µDISS Profiler
Brochure TechNote 4

Posters:
Non-Conventional Approach to Solubility Measurement: in situ Concentration Monitoring With No Need for Filtration (Oct 2006)
A. Avdeef , M. Lontoh, K. Tsinman and O. Tsinman

New Method for UV-in situ Decomposition Study (Oct 2006)
M. Lontoh, K. Tsinman and O. Tsinman

 

µSOL Evolution µSOL Evolution™ - High-Throughput Solubility Analyzer

Brochure

TechNote 1 EvolutionPLUS spec sheet
Installation requirements


Posters:
 Evidence of Compound Aggregation from Solubility-pH Studies: ‘Shift-in-the-pKa’ Applied to Piroxicam (November 2005)
 A. Avdeef, O. Tsinman, D. Voloboy, A. Foreman and P. Nielsen

Solubility for Today's Chemist's Needs: From Discovery to Pre-Formulation (May 2004)
 A. Avdeef, K. Tsinman and O. Tsinman

Solubility for Today's Chemist's Needs: The pION µSOL Solubility Analyzers (Oct 2002)
 J. A. Ruell, A. Avdeef, C. Berger, M. Gelo, P. Nielsen, K. Tsinman and D. Voloboy

High-Throughput Solubility Methods for Small Molecules: The µSOL Solubility Analyzer (Aug 2002)
 J.A. Ruell, A. Avdeef, C. Du and S. Wagner

A New Evolution in Permeability and Solubility Analyzer (Jul 2002)
J. A. Ruell and M. Gelo

HTS Measurement of Physicochemical Properties as Tools in Drug Discovery and Lead Optimization (Aug 2001)
 A. Avdeef, C. Du and M. Strafford

A New Technique for High-Throughput Solubility Assay (Aug 2001)
P. Nielsen, C. Du, K. Tsinman, D. Voloboy and A. Avdeef

High-Throughput Techniques for Measurement of Permeability and Solubility in Drug Discovery (Jun 2001)
 C. Du, K. Tsinman, D. Voloboy, A. Avdeef and P. Nielsen

 
µSOL Explorer µSOL Explorer™ - Entry Level Solubility System
Brochure Spec sheet Installation requirements
 
PAMPA Explorer PAMPA Explorer™ - Entry Level Permeability System
Brochure Spec sheet Installation requirements
 
PAMPA Evolution PAMPA Evolution™ - High-Throughput Permeability Analyzer
Brochure TechNote 1 Evolution96 spec sheet
Installation requirements
EvolutionPLUS spec sheet
Installation requirements

Posters:
 Preformulation Excipient Screening and Evaluation (Oct 2006)
 A. Avdeef, C. Berger, D. Lipp, P. Nielsen and K. Tsinman

Prediction of Brain Uptake/Penetration using a New Brain Lipid in combo PAMPA Model (Oct 2006)
 O. Tsinman, K. Tsinman and A. Avdeef

In vivo - in vitro Permeability Comparisons: Rat in situ Perfusion, Caco-2, and PAMPA (May 2004)
 M. Bermejo, A. Avdeef, A. Ruiz. R. Nalda, J.A. Ruell, O. Tsinman, I. Gonzalez, C. Fernandez, G. Sanchez, T.M. Garrigues and V. Merino

Double-SinkTM PAMPA: The High Throughput Gastrointestinal Absorption Model for 21st Century Drug Discovery (Jan 2003)
J.A. Ruell, A. Avdeef, K. Tsinman, D. Voloboy, C. Berger, and P. Nielsen

A simple PAMPA Filter for Passively Absorbed Compounds (Sep 2002)
J.A. Ruell, A. Avdeef, C. Du and K. Tsinman

PAMPA with Gradient-pH Conditions (Jul 2002)
C. Du, J.A. Ruell, A. Avdeef and K. Tsinman

PAMPA and the Unstirred Water Layer (Jul 2002)
 J.A. Ruell, C. Du, A. Avdeef and K. Tsinman

PAMPA Structure-Permeability Relations of Several Steroids: Development of High-Throughput Gastrointestinal and Blood-Brain Barrier Transport Models (Jul 2002)
 A. Avdeef, J.A. Ruell and C. Du

Filter-Immobilized Artificial Membrane (f-IAM) Permeability Assay: A New High-Throughput In Vitro Drug Absorption Model (Aug 2001)
P. Nielsen, A. Avdeef, K. Tsinman, D. Voloboy, M. Strafford and B. Kenney

Filter-Immobilized Artificial Membrane  Permeability Assay as a Model for Drug Absorption: A Comparison with Caco-2 and MDCK Cells Using the Abraham Equation (Jul 2001)
C. Du, M. Strafford, A. Avdeef, K. Valko and M.H. Abraham

Permeability pH Profiling - Improves Prediction of Oral Absorption (Jun 2001)
 C. Du, K. Tsinman and A. Avdeef

The Utility of Mass Spectrometric Detection for the Determination of Drug Permeability through Filter-Immobilized Artificial Membranes (Jun 2000)
E.H. Block, K. Yu, M. Balogh, B. Kenney, A. Avdeef and C. Berger

 
Gut-Box Gut-Box™ - Stirring Apparatus for pION PAMPA Systems
Brochure
 
*NEW*
pSOL Gemini pSOL Gemini™ - "Gold Standard" Solubility and pKa Analyzer
Brochure Spec sheet Installation requirements

Posters:
 Determination of pKa in Sparingly Soluble Drugs (Oct 2006)
A. Avdeef, C. Berger and D. Lipp

Determination of Drug Solubility using a Potentiometric Acid-Base Titration Method Compared to the Saturation Shake-Flask Method (Jul 2001)
M. Strafford, P. Artursson, K. Luthman, C.R. Brownell and  R. Lyon

Testing the Validity of Solubility Calculations Using the pH-Metric Technique (Jun 2001)
 C. Du and  A. Avdeef

 
*NEW*
Evolution Library Manager - Data Management Software for PAMPA and µSOL Evolution systems
Brochure
 
Analytical Research Lab - Cost-effective pKa, log P, permeability, solubility and dissolution analysis
Brochure
 

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